Watch out for these 9 symptoms of Bone Marrow Cancer


Many people are diagnosed with bone cancer every year and almost half of them die because of it because of the late detection. Bone cancer originates from the cells that make up the interior part of the bones. Bone cancer is classified into two types- primary and secondary.

Primary bone cancer starts from cells in the hard bone tissue. It is a rare type of cancer and accounts for only two in every 1,000 cases of cancers diagnosed. This type of cancer is more common in men than in women.

Secondary bone cancer is a metastatic cancer, meaning – a cancer which started in another part of the body and spreads to the bone. This is more common form of cancer. Cancers of breast, prostate, lung, kidney, and thyroid can spread to the bones and initiate a cancer there. Treatment of this cancer is different from primary cancer.

Here are some symptoms which can possibly indicate bone marrow cancer –

Bone marrow cancer
Image credits – onlymyhealth.com
  1. Bone pain

Intense pain is in bones or joints is one of the major symptoms of bone cancer. This pain can be a result of cancer tumour- from tumour pressing against nearby nerve or organ or as a result of radiation. This pain usually intensifies during night. However, bone pain is also symptom of arthritis or injury.

  1. Easy bone fractures

The cancer affects the bone cells badly and makes them brittle. So if a bone gets fractured with a minor accident or pressure. E.g. Putting pressure or banging against the door slightly can result in fracture. This is a symptom of bone cancer.

  1. Weight loss

Weight loss that cannot be attributed to diet, exercise or any particular treatment can be a symptom of cancer. Here, the body loses its capacity to eliminate wastes and can also result in constipation.

  1. Inflammation

This symptom is common in primary bone cancer where the cancer develops inside the bone. It causes inflammation and swelling in the area where the tumour is present. It also makes skin very tender and sensitive.

Fatigue is a symptom of bone cancer
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  1. Fatigue

Though this is a generalized symptom and can be associated with many other disorders; it is also a result of cancer. If the tiredness and fatigue doesn’t go with enough rest and proper diet, it can be a symptom of cancer.

  1. Anemia

Anemia occurs because the body produces more white blood cells to fight the disease and thus, production of healthy red blood cells decreases. It is one of the symptom of bone cancer.

  1. Appetite loss

As the cancer grows inside the body, the patient loses his energy and willingness to do physical work as well as physical and mental energy. The patient loses his desire to eat as the food no longer seems appetizing. The cancerous cells also absorb nutrients from the food and healthy cells get very little.

  1. Problem in sleeping

As the main symptom is pain in the bones, the person affected with bone cancer finds it extremely difficult sleeping or resting. Also, pain increases more during night and thus makes it hard for a person to have a sound sleep.

  1. Decreased immunity

To fight any disease, body produces extra white blood cells and it results in frequent infections and common diseases like cold, cough, flu, etc.

Our genes have 30% influences on our bone health. Along with our genes, bone health depends on many other factors such as age, diet, and proper exercise. Poor sunlight exposure, overuse of sun blocks, low calcium intake are some causes for lack of Vitamin D. Screening using genetic tests can help you to calculate your risk factors and take necessary measures.

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Fragile Bones? Your Genes Might Be The Reason


Sameer and Raghav met with a small accident during their office picnic at a hill-station. They fell from a same height. Both are almost of similar age. Sameer is a well-built guy, while Raghav is lean and lanky. However, Raghav got just a few bruises and swollen leg, Sameer got a fracture on his arm. How? This is also commonly observed amongst children. Some get a fracture while some just get bruised while playing. The reason behind this can be your genetic make-up.

Genetics and bone health

A new study by researchers at Montreal’s McGill University discovered a rare genetic variant that impacts largely on bone mineral density and the disposition of some people to fracture bones more easily than others. This study tries to identify the rare variants that have a strong influence on common traits and diseases. Upto 75 % of the total genetic effect on bone density depends on a single gene. Compared to the West, the patients of low bone health in India are almost 10 years younger and the number is growing continuously.

In many physical conditions, genes play a crucial role in heritability, i.e. the variation of a condition due to genetics. In case of bone mineral density, it is about 85 percent.

The approach taken in this study included exome sequencing, whole genome sequencing, and genotypic data to find rare and non-coding genetic variants. It allowed them to find a rare non-coding variant that had a four times more effect on bone mineral density than the average effect of all other variants. Thus, it suggests that the gene has an important functional role in bone development.

Image credits - primarycareofappleton.com
Image credits – primarycareofappleton.com

Brittle Bone Disease

Brittle Bone disease is a disorder that results in fragile bones. Our bones are made of a mineral and protein, filled with bone cells. Bone is continually broken down and replaced. When the rate of bone loss is more than the rate of replacement, bones become weak, eventually leading to increased risk of fracture. It is present since birth in individuals who have a family history of the disease. Bone density is a medical term which refers to the amount of mineral matter per square centimeter of bones. This disease affects around 6 to 7 per 100,000 people around the globe. In India, occurrence of this disorder is more common amongst women.

Personal Genome Analysis

Our genes have 30% influence on our bone health. Along with our genes, bone health depends on many other factors such as age, diet, and proper exercise. Poor sunlight exposure, overuse of sun blocks, low calcium intake are some causes for lack of Vitamin D. Datar Genetics Limited offers Personal Genome Analysis- a test with many other parameters, analyses your bone density, and your bone health.

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