Correkt-Chemo – Personalize your Chemotherapy


Cancer is a name given to a collection of related diseases. Cancer can start any place in the body, starting with cells growing out of control and crowding out normal cells. This makes it hard for the body to work the way it should. Cancerous tumors are malignant and they invade nearby tissues, travel to distant places in the body through the blood, forming new tumors far from the original tumors. Cancer can be treated very well for many people and can help them lead full lives.

Various therapies use medicines or drugs to treat cancer. Surgery and radiation therapy remove, kill, or damage cancer cells in a certain area, but chemotherapy can work throughout the whole body. Chemotherapy can kill cancer cells that have metastasized or spread to parts of the body far away from the primary (original) tumor. Multiple drugs with different actions can work together to kill more cancer cells. This can also reduce the chance that the cancer may become resistant to any one chemo drug.

Once a patient is diagnosed with cancer, routinely patient receives the “conventional / standard” chemotherapy regimens. These regimens are common to all patients with that particular cancer type. Such “one size fits all” approach is one of the most important reasons of treatment failure and cancer recurrence. To avoid such “trial and error” approach and to save the precious time, Correkt-chemo is a must for a successful cancer therapy management.

  • What is Correkt-chemo?

It is the only test available that identifies directly, the most effective chemotherapy drugs that can kill cancer cells. In this test, live tumor cells obtained from fresh biopsy are treated with different chemotherapy drugs and their combinations.  The effect of these drugs is studied in real time to analyze the direct efficacy of each cancer drug to kill the cancer cells. This allows oncologists to personalize and improve the treatment by selecting the best suitable drugs before starting chemotherapy.

  • How is Correkt-chemo helpful?

Not all drugs work the same on all patients. Some drugs may not prove beneficial and waste valuable time and resources at this critical point in treatment. With Correkt-chemo test, there is a way to know how effective the chemotherapy will be, before the start of treatment. It will help your oncologist choose the best chemotherapy regimen from the NCCN approved list. Correkt-chemo test directly measures the efficacy of chemotherapy drugs on your live tumor cells and provides a personalized efficacy profile of individual chemotherapy drugs. Thus instead of speculating about how effective chemotherapy will be by costly trial and error, we get that information well before beginning the therapy. It helps to identify at an early stage whether the treatment is likely to work or not and to spare patient’s the unnecessary toxicity of ineffective drugs. It helps to provide patient with the right treatment for the right target without delay.

Knowing the right chemotherapy from the very beginning is the best option. As fresh tumor sample is required, the test can be performed and results can be provided to you and your physician to aid in the determination of the best drugs for you, and you can ensure that you receive the most effective chemotherapy from all available options.

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Watch out for these 9 symptoms of Bone Marrow Cancer


Many people are diagnosed with bone cancer every year and almost half of them die because of it because of the late detection. Bone cancer originates from the cells that make up the interior part of the bones. Bone cancer is classified into two types- primary and secondary.

Primary bone cancer starts from cells in the hard bone tissue. It is a rare type of cancer and accounts for only two in every 1,000 cases of cancers diagnosed. This type of cancer is more common in men than in women.

Secondary bone cancer is a metastatic cancer, meaning – a cancer which started in another part of the body and spreads to the bone. This is more common form of cancer. Cancers of breast, prostate, lung, kidney, and thyroid can spread to the bones and initiate a cancer there. Treatment of this cancer is different from primary cancer.

Here are some symptoms which can possibly indicate bone marrow cancer –

Bone marrow cancer
Image credits – onlymyhealth.com
  1. Bone pain

Intense pain is in bones or joints is one of the major symptoms of bone cancer. This pain can be a result of cancer tumour- from tumour pressing against nearby nerve or organ or as a result of radiation. This pain usually intensifies during night. However, bone pain is also symptom of arthritis or injury.

  1. Easy bone fractures

The cancer affects the bone cells badly and makes them brittle. So if a bone gets fractured with a minor accident or pressure. E.g. Putting pressure or banging against the door slightly can result in fracture. This is a symptom of bone cancer.

  1. Weight loss

Weight loss that cannot be attributed to diet, exercise or any particular treatment can be a symptom of cancer. Here, the body loses its capacity to eliminate wastes and can also result in constipation.

  1. Inflammation

This symptom is common in primary bone cancer where the cancer develops inside the bone. It causes inflammation and swelling in the area where the tumour is present. It also makes skin very tender and sensitive.

Fatigue is a symptom of bone cancer
Image credits – testsieger-berichte.de
  1. Fatigue

Though this is a generalized symptom and can be associated with many other disorders; it is also a result of cancer. If the tiredness and fatigue doesn’t go with enough rest and proper diet, it can be a symptom of cancer.

  1. Anemia

Anemia occurs because the body produces more white blood cells to fight the disease and thus, production of healthy red blood cells decreases. It is one of the symptom of bone cancer.

  1. Appetite loss

As the cancer grows inside the body, the patient loses his energy and willingness to do physical work as well as physical and mental energy. The patient loses his desire to eat as the food no longer seems appetizing. The cancerous cells also absorb nutrients from the food and healthy cells get very little.

  1. Problem in sleeping

As the main symptom is pain in the bones, the person affected with bone cancer finds it extremely difficult sleeping or resting. Also, pain increases more during night and thus makes it hard for a person to have a sound sleep.

  1. Decreased immunity

To fight any disease, body produces extra white blood cells and it results in frequent infections and common diseases like cold, cough, flu, etc.

Our genes have 30% influences on our bone health. Along with our genes, bone health depends on many other factors such as age, diet, and proper exercise. Poor sunlight exposure, overuse of sun blocks, low calcium intake are some causes for lack of Vitamin D. Screening using genetic tests can help you to calculate your risk factors and take necessary measures.

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Fragile Bones? Your Genes Might Be The Reason


Sameer and Raghav met with a small accident during their office picnic at a hill-station. They fell from a same height. Both are almost of similar age. Sameer is a well-built guy, while Raghav is lean and lanky. However, Raghav got just a few bruises and swollen leg, Sameer got a fracture on his arm. How? This is also commonly observed amongst children. Some get a fracture while some just get bruised while playing. The reason behind this can be your genetic make-up.

Genetics and bone health

A new study by researchers at Montreal’s McGill University discovered a rare genetic variant that impacts largely on bone mineral density and the disposition of some people to fracture bones more easily than others. This study tries to identify the rare variants that have a strong influence on common traits and diseases. Upto 75 % of the total genetic effect on bone density depends on a single gene. Compared to the West, the patients of low bone health in India are almost 10 years younger and the number is growing continuously.

In many physical conditions, genes play a crucial role in heritability, i.e. the variation of a condition due to genetics. In case of bone mineral density, it is about 85 percent.

The approach taken in this study included exome sequencing, whole genome sequencing, and genotypic data to find rare and non-coding genetic variants. It allowed them to find a rare non-coding variant that had a four times more effect on bone mineral density than the average effect of all other variants. Thus, it suggests that the gene has an important functional role in bone development.

Image credits - primarycareofappleton.com
Image credits – primarycareofappleton.com

Brittle Bone Disease

Brittle Bone disease is a disorder that results in fragile bones. Our bones are made of a mineral and protein, filled with bone cells. Bone is continually broken down and replaced. When the rate of bone loss is more than the rate of replacement, bones become weak, eventually leading to increased risk of fracture. It is present since birth in individuals who have a family history of the disease. Bone density is a medical term which refers to the amount of mineral matter per square centimeter of bones. This disease affects around 6 to 7 per 100,000 people around the globe. In India, occurrence of this disorder is more common amongst women.

Personal Genome Analysis

Our genes have 30% influence on our bone health. Along with our genes, bone health depends on many other factors such as age, diet, and proper exercise. Poor sunlight exposure, overuse of sun blocks, low calcium intake are some causes for lack of Vitamin D. Datar Genetics Limited offers Personal Genome Analysis- a test with many other parameters, analyses your bone density, and your bone health.

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