Cardio diabetics and Pharmacogenetics

On 2nd July 2008, David Belk, 50, director of a construction firm died of brain hemorrhage. He headed the ball during a veterans’ soccer match. Doctor said that even if he would have been taken to the hospital immediately, he wouldn’t have been saved! So what lead to his death? Mr. Belk, father of two, had a heart pacemaker fitted ten years earlier and was on oral warfarin for anticoagulation which can lead to weakening of blood vessels in the head.
Excessive anticoagulation could have been avoided by Pharmacogenetic tests.

From the above case, you must have realized how important is it to know that which drugs suit our genetic makeup and which don’t.

When we tend to get a common cold or fever, more often than not, we take some medicines on our own without any clinical supervision. Very little do we know how harmful this practice is. Recently, genetic studies have discovered that medicines don’t always work the same way for everyone and could even be fatal to some.

The Indian Pharmacopoeia Commission expressly recognizes that genetic make-up of an individual can impact drug metabolism by as much as 6 to 8 fold and therefore can cause life threatening side effects.

A part of it is genetics and through pharmacogenetics one can learn how you respond to certain medications. The results range from whether the drugs are beneficial, need a different dose due to sensitivity and adverse effects, or even have increased risk for other conditions.

Image credits-
Image credits-

Pharmacogenetics provides personalized drug therapy depending on your genetic makeup, thus maximizing the chances of getting the proper treatment and limiting adverse effects of drugs.

Cardio Diabetics

If you or anyone you know is undergoing a treatment for any cardiovascular disease, it’s advisable to take help of pharmacogenetics. It can help to take well-informed course of treatment for the cardiovascular cases.

This case study will help you to see how pharamacogenetics tests helped a cardiovascular patient.

A 45-year-old man was diagnosed with acute inferior myocardial infarction and underwent emergent coronary angiography (CAG). Two bare-metal stents were deployed in the right coronary artery. After the procedure, antiplatelet therapy with 75 mg Clopidogrel daily was given. However, stent thrombosis occurred three times and he underwent repeat interventions. To investigate the cause of repeated stent thrombosis, the platelet function was measured. The result showed that he did not achieve an adequate antiplatelet effect.

Know the right medications for you!

  1. Get a genetic test to determine your metabolic status. It’s important to be aware of the type of metabolizer you are for each cytochrome P450 enzyme. GeneshieldTM Cardio-Diabetic test at Datar Genetics Limited would help you and your clinician to alter you present medications or dosage. This test has turnaround time of 2 weeks and needs 4ml whole blood/saliva.
  2. Review your results. Know which drug is most effective for you and which wouldn’t have any adverse drug reaction (ADR) on you.

Your result will look like this

Share the information with your doctor and ask them to make changes accordingly in your prescription.

This test also helps you take control of your overall cost of medication by identifying the right medicine for you, from the beginning of the treatment. So talk to your doctor today.


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