Correkt-Chemo – Personalize your Chemotherapy


Cancer is a name given to a collection of related diseases. Cancer can start any place in the body, starting with cells growing out of control and crowding out normal cells. This makes it hard for the body to work the way it should. Cancerous tumors are malignant and they invade nearby tissues, travel to distant places in the body through the blood, forming new tumors far from the original tumors. Cancer can be treated very well for many people and can help them lead full lives.

Various therapies use medicines or drugs to treat cancer. Surgery and radiation therapy remove, kill, or damage cancer cells in a certain area, but chemotherapy can work throughout the whole body. Chemotherapy can kill cancer cells that have metastasized or spread to parts of the body far away from the primary (original) tumor. Multiple drugs with different actions can work together to kill more cancer cells. This can also reduce the chance that the cancer may become resistant to any one chemo drug.

Once a patient is diagnosed with cancer, routinely patient receives the “conventional / standard” chemotherapy regimens. These regimens are common to all patients with that particular cancer type. Such “one size fits all” approach is one of the most important reasons of treatment failure and cancer recurrence. To avoid such “trial and error” approach and to save the precious time, Correkt-chemo is a must for a successful cancer therapy management.

  • What is Correkt-chemo?

It is the only test available that identifies directly, the most effective chemotherapy drugs that can kill cancer cells. In this test, live tumor cells obtained from fresh biopsy are treated with different chemotherapy drugs and their combinations.  The effect of these drugs is studied in real time to analyze the direct efficacy of each cancer drug to kill the cancer cells. This allows oncologists to personalize and improve the treatment by selecting the best suitable drugs before starting chemotherapy.

  • How is Correkt-chemo helpful?

Not all drugs work the same on all patients. Some drugs may not prove beneficial and waste valuable time and resources at this critical point in treatment. With Correkt-chemo test, there is a way to know how effective the chemotherapy will be, before the start of treatment. It will help your oncologist choose the best chemotherapy regimen from the NCCN approved list. Correkt-chemo test directly measures the efficacy of chemotherapy drugs on your live tumor cells and provides a personalized efficacy profile of individual chemotherapy drugs. Thus instead of speculating about how effective chemotherapy will be by costly trial and error, we get that information well before beginning the therapy. It helps to identify at an early stage whether the treatment is likely to work or not and to spare patient’s the unnecessary toxicity of ineffective drugs. It helps to provide patient with the right treatment for the right target without delay.

Knowing the right chemotherapy from the very beginning is the best option. As fresh tumor sample is required, the test can be performed and results can be provided to you and your physician to aid in the determination of the best drugs for you, and you can ensure that you receive the most effective chemotherapy from all available options.

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Exacta – A Test to Accurately Screen The Cancer Mechanism


Cancer is caused due to the mutations in the genes – it is a disease of genes. Just like every human body, each person’s cancer is unique. However, the overall genetic makeup of a particular cancer tumor and the patient is not taken into consideration in the standard approach to the cancer treatment. It results in the failed therapies or aggressive relapse. Thus, it is important that genetic architecture of the cancer tumor is studied extensively before deciding the treatment plan.

This is where genetic screening plays a crucial role. DGL has introduced a high-precision test to screen the cancer – Exacta.

About Exacta

Exacta unfolds the deepest genetic secrets of an individual patient’s cancer by accurate, multi-coordinate analysis of all 22,000 genes in the cancer genome. Exacta reaches the depths of cancer’s mechanisms through 100s of millions of data points. It helps to reveal the driver mutations and pathways that are propelling a particular person’s cancer and can be targeted with precision drugs. Exacta thus enables a highly sophisticated treatment strategy beyond conventional perspective. This is the unmatched strength of Exacta. Exacta is the latest and world’s best molecular analysis for difficult cancers.

How does the test help?

It reports all pathways as per KEGG database to identify the most appropriate gene targets for therapy.

Indication of therapy resistance / Angiogenic / Proliferation / Metastatic / Recurrence Potential.

Gene expression of Primary and Metastasis tumours.

Whole exome analysis of Primary and Metastasis (all NCCN recommended genes and more).

Analysis of all miRNA in the cancer genome.

Whole genome analysis of mtDNA (Primary and Metastasis)

Mutation burden and telomere attrition / compromise.

Tests cytotoxic drug response / resistance of cancer genome.

Screens Germline metabolic response to cytotoxic / small molecule therapy.

Detects loss of Hetrozygosity / Micro Satellite Instability / epigenetic indicators.

This test is important where – 

  • The First Line Therapy has failed
  • Relapse of the cancer
  • High grade or metastatic cancer
  • The Risk of Therapy Failure is high.

It is now indeed important for cancer patients to undergo the screening before rushing into any treatment which may pose a severe threat to the health. Being well-informed helps in taking correct decisions.

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chemotherapy

Correkt-chemo – Test For the Precise Treatment


Once the cancer has been diagnosed, the patient routinely has to go for conventional

chemotherapy regimen. However, these chemo sessions are common to all patients with

that specific cancer type. This uniform approach to the treatment is one of the most

important reasons of treatment fatalities, deaths, and cancer recurrence. ‘One size fits all’

proves harmful in this case.

Cancer has unique properties and differs in every patient and hence every patient responds

in a very different manner to the same chemotherapy. Thus, a few patients undergo

remission whereas few have cancer progression even after receiving cancer treatment. It is

harmful because this cancer progression or failure of treatment becomes evident after

many days of receiving the chemotherapy and after suffering all the side effects of the

chemotherapy.

 

Time & Money

Trial & error approach proves very hazardous in this case the time is very precious for

successful cancer management and this precious time is lost with the conventional method.

At the same time, precious financial resources are wasted in drugs with no benefits and

give harsh side effects. Hence it is very beneficial for the patient and the treating physician,

if it is already known which drugs will give maximum benefit in that individual patient’s

tumor.

 

Why Correkt-chemo?

Correkt-chemo directly tests the effect of chemotherapy / anti- cancer drugs on the

patient’s tumor cells. It helps to customize the treatment plan according to sensitivity and

resistance pattern of the patient’s tumor cells. When armed with this information, patient’s

physician can ensure that they receive the most effective chemotherapy from all available

options. This personalization of the chemotherapy by directly studying effect of

chemotherapy drugs on cells taken from fresh biopsy sample of the tumor – is the Correkt-

chemo test. In this test, fresh tumor cells obtained by biopsy / surgery are treated with

different chemotherapy drugs. The effect of drug is measured directly by its ability to kill

the tumor cells. Consequent upon this information, the drugs are listed in their order of

comparative efficacy to kill the tumor cells.

 

Who should undergo this test?

  • Every cancer patient with or without metastasis, before starting cancer treatment.
  • Every patient who is under treatment for cancer.
  • Every patient in whom the cancer is not responding satisfactorily to therapy.

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Image credits - healthcosmic.com

Comprehensive Hereditary Cancer Screening


Datar Genetics Ltd will be offering Comprehensive Hereditary Cancer screening from 4th Feb to 11th Feb, 2016 to commemorate World Cancer Day – 4th February.

Hereditary cancer is caused because of the inherited mutations in specific genes. People with such mutations run extremely high risk of developing Cancer.          

This screening tests for the risk of various types of cancers such as Breast, Ovarian, Colorectal, Renal, Prostate, Pancreatic, Gastric etc.

Hereditary Cancer Screening is strongly recommended for women who have two or more blood relatives (occurrence in different persons) with Breast/Ovarian Cancer diagnosed at any age.

In men, this screening is recommended for people with personal history of colorectal polyps, obese, smokers, alcoholic etc. and strongly recommended for colorectal cancer or adenomatous polyps in any first-degree relative before age 60, or in 2 or more first-degree relatives at any age.

It is very crucial for men to get tested if they have a first-degree relative with male Breast Cancer/Prostate /Colon cancer diagnosed at early age/ a strong family history of colorectal cancer.

 

[su_youtube_advanced url=”https://youtu.be/c-cAR5Ln1lw” width=”500″ height=”340″ rel=”no”]

 

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Endurance training - cycling

Genetics of Endurance Training


Exercise is one of the most important things for our well-being and good health. Nowadays, people

are well-aware about the health-risks as well the steps they should take to avoid that. No wonder

there are many health centers and gyms sprawled up in almost every corner of the cities.

Endurance training is one of its parts – it includes a long-term, moderate- muscle resistance

exercises that positively affect our health. Along with that, those exercises make losing fat possible

based on an individual’s endurance level and improves cardiac health. However, in spite of working

out a lot and following a rigid diet, it’s hard for some people to maintain that desired level of fitness.

The reason behind it is the person’s genetic make-up.

Along with playing a major role in our response to training, diet, and other external factors, genetic

factors also boosts or limit our physical and mental performance. It affects our potential in sports

and other physical activities.

There are two variations in Endurance –

Aerobic Endurance

Aerobic Endurance – One with oxygen, the body works at such level where the demand for fuel and

oxygen can be fulfilled by the body’s intake. CO2 and water are the only waste products formed

which get eliminated from the body through breathing and sweating.

A research on aerobic endurance shows that certain individuals respond better to training than

others. Thus, even if they have a lesser genetic potential for endurance, they might respond well to

training and develop their potential more than someone compared to someone whose genetic

makeup does not respond to the training.

Anaerobic endurance

This is more severe type of endurance where body uses maximum strength and works very hard

that the demand for oxygen and fuel exceeds the rate of supply (because of the vigorous nature of

the exercise) and the muscles need to depend on stored reserved fuel.

The genes –

When it comes to physical or athletic performance, two genes are widely studied – angiotensin-

converting enzyme gene (ACE) and α-actinin-3 gene (ACTN3). There are two variations found in the

human DNA in the ACE gene. Every person has two copies of the ACE gene; one from mother and

other from the father. Depending on the version of the genes the person receives from each of the

parent, the person’s collection of two can be one of the three combinations of the following – II, ID,

or DD.

The endurance, our genetic make-up and their compatibility to the physical efforts can be gauged

through genetic testing. This test at DGL is as simple and hassle-free as a normal blood test and

turnaround time is 4 weeks. It is recommended for all the people above 18 years of age. It is indeed

necessary to know about our genetic endurance to the exercise so that we can alter our workout

regime accordingly.

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