chemotherapy

Correkt-chemo – Test For the Precise Treatment


Once the cancer has been diagnosed, the patient routinely has to go for conventional

chemotherapy regimen. However, these chemo sessions are common to all patients with

that specific cancer type. This uniform approach to the treatment is one of the most

important reasons of treatment fatalities, deaths, and cancer recurrence. ‘One size fits all’

proves harmful in this case.

Cancer has unique properties and differs in every patient and hence every patient responds

in a very different manner to the same chemotherapy. Thus, a few patients undergo

remission whereas few have cancer progression even after receiving cancer treatment. It is

harmful because this cancer progression or failure of treatment becomes evident after

many days of receiving the chemotherapy and after suffering all the side effects of the

chemotherapy.

 

Time & Money

Trial & error approach proves very hazardous in this case the time is very precious for

successful cancer management and this precious time is lost with the conventional method.

At the same time, precious financial resources are wasted in drugs with no benefits and

give harsh side effects. Hence it is very beneficial for the patient and the treating physician,

if it is already known which drugs will give maximum benefit in that individual patient’s

tumor.

 

Why Correkt-chemo?

Correkt-chemo directly tests the effect of chemotherapy / anti- cancer drugs on the

patient’s tumor cells. It helps to customize the treatment plan according to sensitivity and

resistance pattern of the patient’s tumor cells. When armed with this information, patient’s

physician can ensure that they receive the most effective chemotherapy from all available

options. This personalization of the chemotherapy by directly studying effect of

chemotherapy drugs on cells taken from fresh biopsy sample of the tumor – is the Correkt-

chemo test. In this test, fresh tumor cells obtained by biopsy / surgery are treated with

different chemotherapy drugs. The effect of drug is measured directly by its ability to kill

the tumor cells. Consequent upon this information, the drugs are listed in their order of

comparative efficacy to kill the tumor cells.

 

Who should undergo this test?

  • Every cancer patient with or without metastasis, before starting cancer treatment.
  • Every patient who is under treatment for cancer.
  • Every patient in whom the cancer is not responding satisfactorily to therapy.

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Neurology and pharmacogenetics

Pharmacogenetic analysis for Neurology/Psychiatry


Adverse Drug Reaction (ADR) is one of the most common causes of deaths worldwide. It also causes 50 deaths out of 1000 patients in India. These statistics highlight the importance of correct drugs for the treatment. This is where Pharmacogenetics plays an important role.

What is pharmacogenetics?

Pharmacogenetics is the study of inherited genetic differences in drug metabolism which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.

Why pharmacogenetics?

In a last few years, importance of pharmacogenetics has increased tremendously in medical practice. This testing particularly benefits psychiatric patients as the drugs and medications suggested in the treatments can lead to variety of side-effects. The use of pharmacogenetic screening can help the expert to design psychotropic treatments and make informed decisions which prove to be very useful most of the times.

Many cases and studies have been published in recent times which prove the positive results in the patients. Along with the better outcome, genetic testing also helps to decrease the medical costs. Recently, many studies have been published demonstrating improved patient outcomes and decreased healthcare costs for psychiatric patients who utilize genetic testing.

The very first genotyping test used in psychiatry was Roche’s AmpliChip CYP450 test. It received clearance from FDA in December 2004.

The risk of adverse drug reaction is more in children and adolescents who have metabolic disorders as their system finds it hard to break down the new elements in it.

Pharmacogenetics is important in neurology / psychiatrics because –

  • It gives an insight of patient’s metabolic response
  • Prescribes surer, safer and targeted drug therapy
  • Promotes avoidance of Over-dose/ Under-dose
  • Minimizes Adverse Drug Reaction (ADR)
  • Eliminates trial and error in therapy
  • Offers optimum therapeutic response
  • It’s an affordable and once in a life-time test
  • It protects doctor from medico-legal complications

It is a common belief that high-end medical tests only prescribe equally high-end and expensive treatments. However, it is not the case; pharmacogenetic screening identifies the most effective course of conventional treatments and also suggests equally effective alternate options.

The widespread application and utility of pharmacogenetics in neurology/ psychiatry will only keep increasing along with its knowledge and understanding. With continuous research, it is very vital that medications and drugs will get more narrowed down on the basis of their effectiveness to the patients.

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